Abstract RANTES (regulated upon activation, normal T-cell expressed and secreted), a CC chemokine, appears to play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RR-MS), enhancing the inflammatory response within the nervous system. We have demonstrated that RANTES production is increased in RR-MS compared to controls. Interferon-β-1b (IFN-β-1b) treatment reduces RANTES production in sera and peripheral blood adherent mononuclear cell (PBAM) supernatants both in relapse and remission. IFN-β-1b also reduces RANTES expression in PBAM. Our results suggest that RANTES modulation might represent one of the mechanisms of action of IFN-β-1b in RR-MS. Keywords Chemokines; RANTES; Multiple sclerosis; Interferon-β; Adherent monocytes; RT-PCR

RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with interferon-beta-1b

REALE, Marcella;BONANNI, Laura;DI IORIO, Angelo;CONTI, Pio;
2000-01-01

Abstract

Abstract RANTES (regulated upon activation, normal T-cell expressed and secreted), a CC chemokine, appears to play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RR-MS), enhancing the inflammatory response within the nervous system. We have demonstrated that RANTES production is increased in RR-MS compared to controls. Interferon-β-1b (IFN-β-1b) treatment reduces RANTES production in sera and peripheral blood adherent mononuclear cell (PBAM) supernatants both in relapse and remission. IFN-β-1b also reduces RANTES expression in PBAM. Our results suggest that RANTES modulation might represent one of the mechanisms of action of IFN-β-1b in RR-MS. Keywords Chemokines; RANTES; Multiple sclerosis; Interferon-β; Adherent monocytes; RT-PCR
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/112518
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