Layer by layer (LBL) assembly of poly(sodium 4-styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) was used to coat positively as well as negatively charged liposomes. The adsorption of either polyelectrolyte onto the liposomal surface occurs by means of electrostatic and hydrophobic interactions, depending on the structure of the polymer. The stability of the surface-modified liposomes was evaluated by monitoring the rate of the breakdown induced by the addition of increasing amounts of octaethyleneglycol mono-n-dodecylether (C12E8). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) yielded insight into the morphology of the capsules before and after the impact with the surfactant.

Kinetic evaluation of the effect of layer by layer deposition of polyeletrolytes on the stability of POPC liposomes

ANGELINI, Guido;BONCOMPAGNI, SIMONA;DE MARIA, Paolo;FONTANA, Antonella;GASBARRI, Carla;SIANI, Gabriella
2008-01-01

Abstract

Layer by layer (LBL) assembly of poly(sodium 4-styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) was used to coat positively as well as negatively charged liposomes. The adsorption of either polyelectrolyte onto the liposomal surface occurs by means of electrostatic and hydrophobic interactions, depending on the structure of the polymer. The stability of the surface-modified liposomes was evaluated by monitoring the rate of the breakdown induced by the addition of increasing amounts of octaethyleneglycol mono-n-dodecylether (C12E8). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) yielded insight into the morphology of the capsules before and after the impact with the surfactant.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/116064
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
social impact