Elevated levels of cytokines have been detected in brains of Alzheimer's disease (AD) patients, and altered peripheral levels of IL-1β, TNFα and IL-6 have been reported in these patients. We studied the ability of PBMC from patients with AD, matched with a control group, to release pro- and anti-inflammatory cytokines, and the effect of AChEI treatment on cytokine release. Our data indicates that AChEI treatment down-regulates IL-1, IL-6 and TNF, and up-regulates the expression and production of IL-4 in PBMC in AD patients, and that AChEI leads to the remodelling of the cytokine network, probably acting on the lymphocytic cholinergic system. Keywords Alzheimer's disease; IL-1β; IL-6; TNFα; IL-4; PBMC

Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines.

REALE, Marcella;GAMBI, Francesco;SALONE, ANATOLIA;DE LUCA, Giovanna;CONTI, Pio;
2004-01-01

Abstract

Elevated levels of cytokines have been detected in brains of Alzheimer's disease (AD) patients, and altered peripheral levels of IL-1β, TNFα and IL-6 have been reported in these patients. We studied the ability of PBMC from patients with AD, matched with a control group, to release pro- and anti-inflammatory cytokines, and the effect of AChEI treatment on cytokine release. Our data indicates that AChEI treatment down-regulates IL-1, IL-6 and TNF, and up-regulates the expression and production of IL-4 in PBMC in AD patients, and that AChEI leads to the remodelling of the cytokine network, probably acting on the lymphocytic cholinergic system. Keywords Alzheimer's disease; IL-1β; IL-6; TNFα; IL-4; PBMC
File in questo prodotto:
File Dimensione Formato  
Reale J Neuroimmunol 2004.pdf

Solo gestori archivio

Tipologia: Documento in Post-print
Dimensione 771.58 kB
Formato Adobe PDF
771.58 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/120080
Citazioni
  • ???jsp.display-item.citation.pmc??? 28
  • Scopus 113
  • ???jsp.display-item.citation.isi??? 106
social impact