Abstract Ceramide is a sphingosine-based lipid second messeger molecule that is involved in regulation of differentiation, proliferation, apoptosis, or growth arrest. The pleiotropic nature of ceramide signalling may be due to the fact that it is linked to a variety of receptors in different cell types. Since the ceramide is one of the most hydrophobic molecules in mammalian cells, it tends to remain within the membrane bilayer and may exert its function exclusively at the subcellular site of production. Ceramide is generated from sphingomyelin (SM) by the action of several isoforms of SMase (neutral, acid and alkaline SMase) or by de novo synthesis co-ordinated through the enzyme ceramide synthase. In this chapter, the pathways of ceramide generation, the interaction of ceramide with several enzymes and apoptotic signalling cascades are describe
Ceramide and apoptosis
DI MARZIO, Luisa;
1999-01-01
Abstract
Abstract Ceramide is a sphingosine-based lipid second messeger molecule that is involved in regulation of differentiation, proliferation, apoptosis, or growth arrest. The pleiotropic nature of ceramide signalling may be due to the fact that it is linked to a variety of receptors in different cell types. Since the ceramide is one of the most hydrophobic molecules in mammalian cells, it tends to remain within the membrane bilayer and may exert its function exclusively at the subcellular site of production. Ceramide is generated from sphingomyelin (SM) by the action of several isoforms of SMase (neutral, acid and alkaline SMase) or by de novo synthesis co-ordinated through the enzyme ceramide synthase. In this chapter, the pathways of ceramide generation, the interaction of ceramide with several enzymes and apoptotic signalling cascades are describeI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
