LADU, SARA
LADU, SARA
DIPARTIMENTO DI MEDICINA E SCIENZE DELL'INVECCHIAMENTO (attivo dal 01/01/2005 al 01/01/2014)
Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease.
2008-01-01 Calvisi, Df; Pinna, F; Ladu, Sara; Pellegrino, R; Muroni, Mr; Simile, Mm; Frau, M; Tomasi, Ml; De Miglio, Mr; Seddaiu, Ma; Daino, L; Sanna, V; Feo, F; Pascale, Rm
Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.
2004-01-01 Calvisi, Df; Ladu, Sara; Factor, Vm; Thorgeirsson, S. S.
Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer.
2005-01-01 Calvisi, Df; Conner, Ea; Ladu, Sara; Lemmer, Er; Factor, Vm; Thorgeirsson, Ss
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
2011-01-01 Calvisi, Df; Simile, Mm; Ladu, Sara; Frau, M; Evert, M; Tomasi, Ml; Demartis, Mi; Daino, L; Seddaiu, Ma; Brozzetti, S; Feo, F; Pascale, Rm
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
2011-01-01 Ho, C; Wang, C; Mattu, S; Destefanis, G; Ladu, Sara; Delogu, S; Armbruster, J; Fan, L; Lee, Sa; Jiang, L; Dombrowski, F; Evert, M; Chen, X; Calvisi, D. F.
Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis.
2007-01-01 Calvisi, Df; Simile, Mm; Ladu, Sara; Pellegrino, R; De Murtas, V; Pinna, F; Tomasi, Ml; Frau, M; Virdis, P; De Miglio, Mr; Muroni, Mr; Pascale, Rm; Feo, F.
Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.
2002-01-01 De Miglio, Mr; Pascale, Rm; Simile, Mm; Muroni, Mr; Calvisi, Df; Virdis, P; Bosinco, Gm; Frau, M; Seddaiu, Ma; Ladu, Sara; Feo, F.
Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value
2013-01-01 Evert, M.; Frau, M.; Tomasi, M. L.; Latte, G.; Simile, M. M.; Seddaiu, M. A.; Zimmermann, A.; Ladu, Sara; Staniscia, Tommaso; Brozzetti, S.; Solinas, G.; Dombrowski, F.; Feo, F.; Pascale, R. M.; Calvisi, D. F.
Disregulation of E-cadherin in transgenic mouse models of liver cancer.
2004-01-01 Calvisi, Df; Ladu, Sara; Conner, Ea; Factor, Vm; Thorgeirsson, S. S.
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
2004-01-01 Calvisi, Df; Factor, Vm; Ladu, Sara; Conner, Ea; Thorgeirsson, S. S.
Downregulation of PH domain leucine-rich repeat protein phosphatases (PHLPPs) identifies a subgroup of human hepatocellular and colorectal carcinomas with elevated levels of activated AKT and low apoptosis rate
2011-01-01 Ladu, Sara; Staniscia, Tommaso; Raffaella, M. D.; Giuseppe, B; Romano, Ferdinando; Calvisi, D.
Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma.
2008-01-01 Calvisi, Df; Pinna, F; Meloni, F; Ladu, Sara; Pellegrino, R; Sini, M; Daino, L; Simile, Mm; De Miglio, Mr; Virdis, P; Frau, M; Tomasi, Ml; Seddaiu, Ma; Muroni, Mr; Feo, F; Pascale, Rm
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.
2008-01-01 Ladu, Sara; Calvisi, Df; Conner, Ea; Farina, M; Factor, Vm; Thorgeirsson, Ss
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC.
2009-01-01 Calvisi, Df; Pinna, F; Ladu, Sara; Pellegrino, R; Simile, Mm; Frau, M; De Miglio, Mr; Tomasi, Ml; Sanna, V; Muroni, Mr; Feo, F; Pascale, Rm
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer.
2011-01-01 Calvisi, Df; Ladu, Sara; Conner, Ea; Seo, D; Hsieh, Jt; Factor, Vm; Thorgeirsson, Ss
Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways
2012-01-01 Wang, C; Delogu, S; Ho, C; Lee, Sa; Gui, B; Jiang, L; Ladu, Sara; Cigliano, A; Dombrowski, F; Evert, M; Calvisi, Df; Chen, X.
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.
2011-01-01 Calvisi, Df; Wang, C; Ho, C; Ladu, Sara; Lee, Sa; Mattu, S; Destefanis, G; Delogu, S; Zimmermann, A; Ericsson, J; Brozzetti, S; Staniscia, Tommaso; Chen, X; Dombrowski, F; Evert, M.
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma.
2007-01-01 Calvisi, Df; Ladu, Sara; Gorden, A; Farina, M; Lee, Js; Conner, Ea; Schroeder, I; Factor, Vm; Thorgeirsson, S. S.
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
2011-01-01 Frau, M; Ladu, Sara; Calvisi, Df; Simile, Mm; Bonelli, P; Daino, L; Tomasi, Ml; Seddaiu, Ma; Feo, F; Pascale, R. M.
Oncogenic and tumor suppressive roles of Polo-like kinases in human hepatocellular carcinoma (p NA).
2010-01-01 Pellegrino, R.; Calvisi, D. F.; Ladu, Sara; Ehemann, V; Staniscia, Tommaso; Evert, M; Dombrowski, F; Schirmacher, P; Longerich, T.