The present invention reports the synthesis and characterization of innovative PEGylated liposomes targeting therapeutic anti-apoptotic protein KillerTRAIL and the use of resulting therapeutic and targeted nanocarirers for anti-cancer and anti-inflammatory therapies. The synthesis of KillerTRAIL PEGylated liposomes were carried out by the conjugation of therapeutic proteins on the surface of nanocarriers and the anti-cancer activity in vitro was carried out in breast cancer cells which are used as cancer model for the experimetns.
Liposomal system with Killer TNF-apoptosis induced ligand (KillerTRAIL), pro-apoptotic-directing.
Celia C;Cilurzo F;
2021-01-01
Abstract
The present invention reports the synthesis and characterization of innovative PEGylated liposomes targeting therapeutic anti-apoptotic protein KillerTRAIL and the use of resulting therapeutic and targeted nanocarirers for anti-cancer and anti-inflammatory therapies. The synthesis of KillerTRAIL PEGylated liposomes were carried out by the conjugation of therapeutic proteins on the surface of nanocarriers and the anti-cancer activity in vitro was carried out in breast cancer cells which are used as cancer model for the experimetns.File in questo prodotto:
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