Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electronwithdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin- and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity.
Synthesis and antibacterial evaluation of oxazolidin-2-ones structurally related to linezolid
AMMAZZALORSO, Alessandra;AMOROSO, Rosa;BETTONI, Giancarlo;FANTACUZZI, MARIALUIGIA;DE FILIPPIS, Barbara;GIAMPIETRO, Letizia;MACCALLINI, Cristina;PALUDI, Domenico;TRICCA, Maria Luisa
2004-01-01
Abstract
Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electronwithdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin- and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity.File in questo prodotto:
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