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Paleoseismological Constraints on the Anghiari Normal Fault (Northern Apennines, Italy) and Potential Implications for the Activity of the Altotiberina Low‐Angle Normal Fault

The NE-dipping Anghiari normal fault, bounding to the west the Sansepolcro basin in the Upper Tiber Valley (northern Apennines), is thought to be a synthetic splay of the Altotiberina low-angle normal fault (LANF), an active ENE-dipping extensional detachment whose seismogenic behavior is debated. In order to assess the Anghiari fault capability to break the surface during strong earthquakes and be the source of historical earthquakes, we acquired high resolution topographic data, performed f...

3D-informed targeting of the Trop-2 signal-activation site drives selective cancer vulnerability

: Next-generation Trop-2-targeted therapy against advanced cancers is hampered by expression of Trop-2 in normal tissues. We discovered that Trop-2 undergoes proteolytic activation by ADAM10 in cancer cells, leading to the exposure of a previously inaccessible protein groove flanked by two N-glycosylation sites. We designed a recognition strategy for this region, to drive selective cancer vulnerability in patients. Most undiscriminating anti-Trop-2 monoclonal antibodies (mAb) recognize a sing...

Artificial intelligence and "the Art of Kintsugi" in Anesthesiology: ten influential papers for clinical users

Artificial intelligence refers to the simulation of human intelligence in machines that are programmed to think like humans and mimic their actions. In the present review we chose ten influential papers from the last five years and through Kintsugi, shed the light on recent evolution of artificial intelligence in anesthesiology. A comprehensive search in in Medline, Embase, Web of Science and Scopus databases was conducted. Each author searched the databases independently and created a list o...

Impact of dual antiplatelet therapy after coronary artery bypass surgery on 1-year outcomes in the Arterial Revascularization Trial

OBJECTIVES: There is still little evidence to boldport routine dual antiplatelet therapy (DAPT) with P2Y12 antagonists following coronary artery bypass grafting (CABG). The Arterial Revascularization Trial (ART) was designed to compare 10-year survival after bilateral versus single internal thoracic artery grafting. We aimed to get insights into the effect of DAPT (with clopidogrel) following CABG on 1-year outcomes by performing a post hoc ART analysis.METHODS: Among patients enrolled in the...

Complexity of coronary artery disease affects outcome of patients undergoing coronary artery bypass grafting with impaired left ventricular function

Objective: To determine whether the SYNTAX score can predict the outcomes of patients with left ventricular dysfunction undergoing coronary artery bypass grafting.Methods: We studied a consecutive series of 191 patients (mean age, 67 +/- 10 years) with a left ventricular ejection fraction of 40% or less who were undergoing isolated coronary artery bypass grafting. All patients were stratified according to their SYNTAX score, indicating coronary artery disease complexity: low, 0 to 22; interme...

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