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The Protective Effects of an Aged Black Garlic Water Extract on the Prostate

Chronic inflammation is a recognized risk factor for various cancers, including prostate cancer (PCa). We aim to explore the potential protective effects of aged black garlic extract (ABGE) against inflammation-induced prostate damage and its impact on prostate cancer cell lines. We used an ex vivo model of inflammation induced by Escherichia coli lipopolysaccharide (LPS) on C57BL/6 male mouse prostate specimens to investigate the anti-inflammatory properties of ABGE. The gene expression leve...

Modulation of inflammatory pathway in human gingival fibroblasts exposed to resinous materials

The goal of this work was to evaluate the anti-inflammatory effects of two resins, Bis-GMA-based resin (ProTemp 4™) and PMMA-based resin (Coldpac), used in dentistry for temporary prosthetics treatments, in the modulation of the inflammatory pathway NFkBp65/NLRP3/IL-1β. The protein expression of inflammatory markers was evaluated in an in vitro model of primary human gingival fibroblasts (hGFs) by immunofluorescence analysis while the study of the ultra-morphological analysis was performed th...

Reprogramming methods for induced pluripotent stem cells generation

Regenerative medicine expects to replace the function of tissue or organs damaged by disease, trauma, or congenital issues. The tools used to realize these outcomes are tissue engineering and cellular therapies. Cellular therapy is considered a regenerative medicine strategy based on the use of stem cells. Pluripotent stem cells are the hotspots of cellular therapy due to their features that have been showed promising results. Embryonic stem cells (ESCs) are pluripotent, self-renewing cells t...

Assessment of the in-vitro toxicity and in-vivo therapeutic capabilities of Juglans regia on human prostate cancer and prostatic hyperplasia in rats

Benign prostatic hyperplasia (BPH) and prostatic cancer are aging-associated urological conditions in men. While significant advances have been made in relation to treatment, poor response, treatment resistance and adverse side-effects limit currently available therapies. The possible antiproliferative and/or ameliorative potentials of Juglans regia have been reported, however, there is a dearth of scientific information on its effect on BPH or prostatic cancer. In this study, in-vivo and in-...

Evidence for Impaired Renin Activity in Postural Orthostatic Tachycardia Syndrome

Background: Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous condition predominantly affecting autonomic control of the cardiovascular system. Its extensive symptom diversity implies multi-organ involvement that interacts in ways still requiring full exploration. Current understanding of POTS pathophysiology suggests alterations in the renin-angiotensin-aldosterone system as a possible contributing factor. Therefore, we investigated the relationship between the activity of ...

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