Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism. Methods: Eightyrandomizedsubjectsreceivedequi-iodineintravenousdoses(48g)ofiomeprol400(n=40)oriodixanol320(n=40),viapower injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation. Results: Therewerenobetween-groupdifferences(p>0.05)indemographics.Pulmonaryarteryattenuationwassignificantly(p≤0.03)higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted. Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.
MDCT angiography for detection of pulmonary emboli: Comparison between equi-iodine doses of iomeprol 400mgI/mL and iodixanol 320mgI/mL.
STORTO, MARIA LUIGIA;
2008-01-01
Abstract
Objectives: To compare iomeprol 400 and iodixanol 320 in pulmonary artery MDCTA in subjects with suspected pulmonary embolism. Methods: Eightyrandomizedsubjectsreceivedequi-iodineintravenousdoses(48g)ofiomeprol400(n=40)oriodixanol320(n=40),viapower injector at 4 mL/s. Four-row (35 subjects) and 64-row (45 subjects) scanners were used. Lumen attenuation was determined on-site and by two off-site blinded readers in the main, lobar, segmental and subsegmental pulmonary arteries. Statistical comparison between groups was performed for demographics and lumen attenuation. Results: Therewerenobetween-groupdifferences(p>0.05)indemographics.Pulmonaryarteryattenuationwassignificantly(p≤0.03)higher with iomeprol 400 for all readers. Attenuation quality was excellent in more patients after iomeprol 400 than after iodixanol-320 (80% vs. 62.5%; 82.5% vs. 77.5%; off-site readers 1 and 2, respectively). No safety concerns were noted. Conclusion: The greater iodine delivery rate achievable with iomeprol 400 compared to iodixanol-320 at equi-iodine dose and injection rate permits consistently greater attenuation at all levels of the pulmonary arterial tree.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
