Rats with an artificial stone in the left ureter display spontaneous pain behavior (ureteral ‘crises’) and referred hyperalgesia/contraction in the ipsilateral oblique musculature. To evaluate neuronal activation in both sensitive and motor pathways in this model, c-Fos expression was studied in the spinal cord of calculosis rats vs. sham controls. Fos-labeled cells were never observed in sham controls. In stone rats, they were found in the T10-L2 segments, throughout the dorsal horn, significantly more on the left than the right side (P<0.002). Fos-labeled cells were also found in lamina IX, containing motoneurons; at the T11-T12 level, these were significantly more on the left than the right side (P<0.03). Nociceptive input from the ureter thus activates not only sensory but also efferent neurons in the spinal cord, suggesting the triggering of reflex arcs by the visceral focus.

c- Fos expression in the spinal cord of female rats with artificial ureteric calculosis

AFFAITATI, GIANNA PIA;LERZA, ROSANNA;VECCHIET, Leonardo;LAPENNA, Domenico;GIAMBERARDINO, Maria Adele
2004-01-01

Abstract

Rats with an artificial stone in the left ureter display spontaneous pain behavior (ureteral ‘crises’) and referred hyperalgesia/contraction in the ipsilateral oblique musculature. To evaluate neuronal activation in both sensitive and motor pathways in this model, c-Fos expression was studied in the spinal cord of calculosis rats vs. sham controls. Fos-labeled cells were never observed in sham controls. In stone rats, they were found in the T10-L2 segments, throughout the dorsal horn, significantly more on the left than the right side (P<0.002). Fos-labeled cells were also found in lamina IX, containing motoneurons; at the T11-T12 level, these were significantly more on the left than the right side (P<0.03). Nociceptive input from the ureter thus activates not only sensory but also efferent neurons in the spinal cord, suggesting the triggering of reflex arcs by the visceral focus.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/113392
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