Recent studies suggest the involvement of inflammatory mechanisms in the progression of atherosclerosis. Coculturing cysteinyl leukotriene D-4 with vascular smooth muscle cells (VSMC) produced an increased cell proliferation, as assessed by [H-3]-Thymidine incorporation studies, as well as cell count. MK-571, a specific leukotriene D-4 (LTD(4)) receptor antagonist, inhibited the mitogenic effect induced by LTD(4). Futhermore the autocrine production of interleukin-1 (IL-1), concomitant to LTD, stimulation, was again controlled by MK-571. A new role for MK-571 may possibly be suggested in the control of the atherogenic process.
Effect of MK-571, a selective leukotriene D4 receptor antagonist, on vascular smooth muscle cell proliferation and interleukin 1 release
PORRECA, Ettore;REALE, Marcella;BARBACANE, Renato Carmine;CASTELLANI, Maria Luisa;CIPOLLONE, Francesco;CONTI, Pio;CUCCURULLO, Franco
1994-01-01
Abstract
Recent studies suggest the involvement of inflammatory mechanisms in the progression of atherosclerosis. Coculturing cysteinyl leukotriene D-4 with vascular smooth muscle cells (VSMC) produced an increased cell proliferation, as assessed by [H-3]-Thymidine incorporation studies, as well as cell count. MK-571, a specific leukotriene D-4 (LTD(4)) receptor antagonist, inhibited the mitogenic effect induced by LTD(4). Futhermore the autocrine production of interleukin-1 (IL-1), concomitant to LTD, stimulation, was again controlled by MK-571. A new role for MK-571 may possibly be suggested in the control of the atherogenic process.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
