Recent reports have noted the presence of novel mutations of the epidermal growth factor receptor (EGFR) gene in small samples of DNA extracted from paraffin-embedded sections or laser-microdissected specimens.1,2 Nagahara et al.1 reported EGFR mutations in colon carcinomas. These mutations were novel G→A or A→G transitions. Similarly, Tsao et al. (July 14 issue)2 report that 24 (53 percent) of the mutations they found in specimens of non–small-cell lung cancers were novel variant mutations; 22 (92 percent) of these mutations were C→T/G→A or A→G/T→C transitions. These mutations had not been reported previously in more than 2000 analyses for EGFR mutations performed on DNA extracted from pieces of frozen tumors.
Assessing EGFR mutations.
MARCHETTI, Antonio;FELICIONI, LARA BARBARA;BUTTITTA, Fiamma
2006-01-01
Abstract
Recent reports have noted the presence of novel mutations of the epidermal growth factor receptor (EGFR) gene in small samples of DNA extracted from paraffin-embedded sections or laser-microdissected specimens.1,2 Nagahara et al.1 reported EGFR mutations in colon carcinomas. These mutations were novel G→A or A→G transitions. Similarly, Tsao et al. (July 14 issue)2 report that 24 (53 percent) of the mutations they found in specimens of non–small-cell lung cancers were novel variant mutations; 22 (92 percent) of these mutations were C→T/G→A or A→G/T→C transitions. These mutations had not been reported previously in more than 2000 analyses for EGFR mutations performed on DNA extracted from pieces of frozen tumors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
