Abstract We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon β, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon β might represent an adjunctive therapy in CIDP both acting on a defective blood–nerve barrier and normalizing an otherwise defective suppressor cell function. Keywords Chronic inflammatory demyelinating polyneuropathy; Myelin associated glycoprotein; Sulfated glucuronyl paragloboside; Suppressor cell function; Recombinant human IFNβ1a

Interferon beta normalizes suppressor cell function in dysimmune neuropathies.

DE LUCA, Giovanna;LUGARESI, Alessandra;IARLORI, Carla;UNCINI, Antonino;GAMBI, Domenico
1998

Abstract

Abstract We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon β, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon β might represent an adjunctive therapy in CIDP both acting on a defective blood–nerve barrier and normalizing an otherwise defective suppressor cell function. Keywords Chronic inflammatory demyelinating polyneuropathy; Myelin associated glycoprotein; Sulfated glucuronyl paragloboside; Suppressor cell function; Recombinant human IFNβ1a
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/120268
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 21
social impact