-2-Bromoesters enriched in the (S,R)-diastereoisomer can be easily pre pared by coupling of racemic 2-bromoacids with (R)-pantolactone. Displacement of the bromine atom with nucleophiles, under suitable reaction conditions, occurs without epimerization of starting compounds, giving (R,R)-2-substituted carboxylic acid derivatives.

Synthesis of diastereomerically enriched 2-bromoesters and their reaction with nucleophiles

AMMAZZALORSO, Alessandra;AMOROSO, Rosa;BETTONI, Giancarlo;DE FILIPPIS, Barbara
2001

Abstract

-2-Bromoesters enriched in the (S,R)-diastereoisomer can be easily pre pared by coupling of racemic 2-bromoacids with (R)-pantolactone. Displacement of the bromine atom with nucleophiles, under suitable reaction conditions, occurs without epimerization of starting compounds, giving (R,R)-2-substituted carboxylic acid derivatives.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11564/121630
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