-2-Bromoesters enriched in the (S,R)-diastereoisomer can be easily pre pared by coupling of racemic 2-bromoacids with (R)-pantolactone. Displacement of the bromine atom with nucleophiles, under suitable reaction conditions, occurs without epimerization of starting compounds, giving (R,R)-2-substituted carboxylic acid derivatives.
Titolo: | Synthesis of diastereomerically enriched 2-bromoesters and their reaction with nucleophiles |
Autori: | |
Data di pubblicazione: | 2001 |
Rivista: | |
Abstract: | -2-Bromoesters enriched in the (S,R)-diastereoisomer can be easily pre pared by coupling of racemic 2-bromoacids with (R)-pantolactone. Displacement of the bromine atom with nucleophiles, under suitable reaction conditions, occurs without epimerization of starting compounds, giving (R,R)-2-substituted carboxylic acid derivatives. |
Handle: | http://hdl.handle.net/11564/121630 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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