-2-Bromoesters enriched in the (S,R)-diastereoisomer can be easily pre pared by coupling of racemic 2-bromoacids with (R)-pantolactone. Displacement of the bromine atom with nucleophiles, under suitable reaction conditions, occurs without epimerization of starting compounds, giving (R,R)-2-substituted carboxylic acid derivatives.
Synthesis of diastereomerically enriched 2-bromoesters and their reaction with nucleophiles
AMMAZZALORSO, Alessandra;AMOROSO, Rosa;BETTONI, Giancarlo;DE FILIPPIS, Barbara
2001-01-01
Abstract
-2-Bromoesters enriched in the (S,R)-diastereoisomer can be easily pre pared by coupling of racemic 2-bromoacids with (R)-pantolactone. Displacement of the bromine atom with nucleophiles, under suitable reaction conditions, occurs without epimerization of starting compounds, giving (R,R)-2-substituted carboxylic acid derivatives.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
