To assess metabolic alterations and/or abnormal fat distribution in Human Immunodeficiency Virus (HIV) -infected women undergoing Highly Active Antiretroviral Therapy (HAART), a case-control study was carried out in a population of twenty-two HIV-infected, normal weight, non-diabetic, normotensive women. Twenty-five healthy non infected subjects matched for sex, age and Body Mass Index (BMI) were also included as a control group. Blood samples were collected for leptin and insulin measurements. Fasting glucose, triglycerides, total cholesterol and HDL-cholesterol were also measured. Insulin resistance was determined using the homeostasis model assessment index (HOMA-IR). Body fat distribution was evaluated using waist-to-hip ratio (WHR), Bioelectric Impedance Analysis (BIA) and abdominal CT-scan. Immunologic and virologic parameters included CD4- and CD8-T cell counts and HIV-RNA levels. HIV-infected patients showed higher levels of total cholesterol, LDL-cholesterol and triglycerides (p<0.05), higher fasting insulin and HOMA-IR (p<0.001), lower levels of HDL-cholesterol (p<0.001) and serum leptin (p<0.001) than the control group. With regard to body fat distribution, no statistically significant difference between cases and controls was found. Among the control women leptin levels were positively correlated with body fat distribution parameters (p<0.001). Copyright © by BIOLIFE.

Metabolic modifications in HIV-infected women

Vecchiet J.
;
Falasca K.;Zingariello P.;Manigrasso M. R.;Dalessandro M.;Capani F.;Paganelli R.;Pizzigallo E.;Guagnano M. T.
2004

Abstract

To assess metabolic alterations and/or abnormal fat distribution in Human Immunodeficiency Virus (HIV) -infected women undergoing Highly Active Antiretroviral Therapy (HAART), a case-control study was carried out in a population of twenty-two HIV-infected, normal weight, non-diabetic, normotensive women. Twenty-five healthy non infected subjects matched for sex, age and Body Mass Index (BMI) were also included as a control group. Blood samples were collected for leptin and insulin measurements. Fasting glucose, triglycerides, total cholesterol and HDL-cholesterol were also measured. Insulin resistance was determined using the homeostasis model assessment index (HOMA-IR). Body fat distribution was evaluated using waist-to-hip ratio (WHR), Bioelectric Impedance Analysis (BIA) and abdominal CT-scan. Immunologic and virologic parameters included CD4- and CD8-T cell counts and HIV-RNA levels. HIV-infected patients showed higher levels of total cholesterol, LDL-cholesterol and triglycerides (p<0.05), higher fasting insulin and HOMA-IR (p<0.001), lower levels of HDL-cholesterol (p<0.001) and serum leptin (p<0.001) than the control group. With regard to body fat distribution, no statistically significant difference between cases and controls was found. Among the control women leptin levels were positively correlated with body fat distribution parameters (p<0.001). Copyright © by BIOLIFE.
File in questo prodotto:
File Dimensione Formato  
Eur J Inflamm - metabolic .. in HIV...pdf

Solo gestori archivio

Descrizione: Research Article
Tipologia: PDF editoriale
Dimensione 705.08 kB
Formato Adobe PDF
705.08 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/157793
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact