Interferon-gamma (IFN-gamma) induces programmed cell death in differentiated human leukemic B cell lines.

Trubiani, Oriana; Bosco, D; Di Primio, R.

doi:10.1006/excr.1994.1309

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Interferons (IFNs) are cytokines that exert an antiviral effect on target cells and possess immunomodulatory and antitumor properties. In this study we have investigated the effects of human recombinant IFN-gamma on human leukemic B cell lines at different stages of maturation. Our data show that in Burkitt's lymphoma RAMOS-1 B cells IFN-gamma induces a reduction of cell growth and a clonal selection via programmed cell death; in contrast, IFN-gamma treatment of KM-3 pre-B cells does not induce biochemical and morphological changes as shown by electron microscope analysis and DNA gel electrophoresis.

Titolo:	Interferon-gamma (IFN-gamma) induces programmed cell death in differentiated human leukemic B cell lines.
Autori:	TRUBIANI, Oriana Bosco D Di Primio R. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1994
Rivista:	EXPERIMENTAL CELL RESEARCH
Abstract:	Interferons (IFNs) are cytokines that exert an antiviral effect on target cells and possess immunomodulatory and antitumor properties. In this study we have investigated the effects of human recombinant IFN-gamma on human leukemic B cell lines at different stages of maturation. Our data show that in Burkitt's lymphoma RAMOS-1 B cells IFN-gamma induces a reduction of cell growth and a clonal selection via programmed cell death; in contrast, IFN-gamma treatment of KM-3 pre-B cells does not induce biochemical and morphological changes as shown by electron microscope analysis and DNA gel electrophoresis.
Handle:	http://hdl.handle.net/11564/163438
Appare nelle tipologie:	1.1 Articolo in rivista

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