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EnglishInterferons (IFNs) are cytokines that exert an antiviral effect on target cells and possess immunomodulatory and antitumor properties. In this study we have investigated the effects of human recombinant IFN-gamma on human leukemic B cell lines at different stages of maturation. Our data show that in Burkitt's lymphoma RAMOS-1 B cells IFN-gamma induces a reduction of cell growth and a clonal selection via programmed cell death; in contrast, IFN-gamma treatment of KM-3 pre-B cells does not induce biochemical and morphological changes as shown by electron microscope analysis and DNA gel electrophoresis.
| Titolo: | Interferon-gamma (IFN-gamma) induces programmed cell death in differentiated human leukemic B cell lines. |
| Autori: | |
| Data di pubblicazione: | 1994 |
| Rivista: | |
| Abstract: | Interferons (IFNs) are cytokines that exert an antiviral effect on target cells and possess immunomodulatory and antitumor properties. In this study we have investigated the effects of human recombinant IFN-gamma on human leukemic B cell lines at different stages of maturation. Our data show that in Burkitt's lymphoma RAMOS-1 B cells IFN-gamma induces a reduction of cell growth and a clonal selection via programmed cell death; in contrast, IFN-gamma treatment of KM-3 pre-B cells does not induce biochemical and morphological changes as shown by electron microscope analysis and DNA gel electrophoresis. |
| Handle: | http://hdl.handle.net/11564/163438 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Interferon-gamma 1994.pdf | Documento in Post-print | PUBBLICO - Pubblico con Copyright | Open Access Visualizza/Apri |
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