To investigate the possible efficacy of amantadine in the control of pathological gambling (PG) associated with Parkinson’s Disease (PD), 17 PD patients with PG were randomly selected for a double blind cross-over study with amantadine 200 mg/day vs. placebo and an open follow-up. Assessments included PG specific scales (Y-BOCS for PG, G-SAS, SOGS) and assessment of expenditures and time spent gambling. Amantadine abolished or reduced PG in all treated patients, as confirmed by scale score and daily expenditures reduction. Amantadine might be useful to treat PG. Effect of amantadine, acting as an antiglutamatergic agent, opens also new insights in the pathogenesis of PG.
Pathological Gambling in PD is reduced by Amantadine
THOMAS, Astrid Maria;BONANNI, Laura;GAMBI, Francesco;DI IORIO, Angelo;ONOFRJ, Marco
2010-01-01
Abstract
To investigate the possible efficacy of amantadine in the control of pathological gambling (PG) associated with Parkinson’s Disease (PD), 17 PD patients with PG were randomly selected for a double blind cross-over study with amantadine 200 mg/day vs. placebo and an open follow-up. Assessments included PG specific scales (Y-BOCS for PG, G-SAS, SOGS) and assessment of expenditures and time spent gambling. Amantadine abolished or reduced PG in all treated patients, as confirmed by scale score and daily expenditures reduction. Amantadine might be useful to treat PG. Effect of amantadine, acting as an antiglutamatergic agent, opens also new insights in the pathogenesis of PG.| File | Dimensione | Formato | |
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