IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis because of the T cells and macrophages that invade the synovial fluid. These finding support a role for IL-18 in inflammation, allergy and immune diseases.
Impact of IL-18 on inflammation
TRIPODI, Domenico;CASTELLANI, Maria Luisa;FELACO, PAOLO;TONIATO, ELENA;DE LUTIIS, Maria Anna;FULCHERI, Mario;TETE', Stefano;SALINI, VINCENZO;SABATINO, Giuseppe;
2011-01-01
Abstract
IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis because of the T cells and macrophages that invade the synovial fluid. These finding support a role for IL-18 in inflammation, allergy and immune diseases.File in questo prodotto:
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