Purpose: The aim of the present study was to perform a comparative histological and immunohistochemical evaluation of microvessel density, vascular endothelial growth factor, and nitric oxide synthase (NOS) expression in sinus augmentation using autologous bone alone or in combination with equine bone. Materials and Methods: Sixteen patients underwent sinus augmentation with autologous bone and a 50: 50 mixture of autologous and equine bone. Control cores were harvested from preexisting nonaugmented bone under the sinus floor. The specimens were processed for immunohistochemistry. Results: The greatest values of microvessel density were found in the sites grafted with autologous bone with significant differences between control versus autologous group (P < 0.01) and control versus autologous + equine group (P < 0.01). The higher and lower intensities of vascular endothelial growth factor and NOS3 expression were prevalent in the sites grafted with autologous bone with significant differences with the controls (P < 0.05). No significant differences (P > 0.05) were found in the NOS1 expression among the groups. Conclusion: The results obtained showed that the mixture of autologous and equine bone was biocompatible, and its use was associated with new blood vessels ingrowth during healing, which has been found to be extremely important for bone formation.

Sinus lift with autologous bone alone or in addition to equine bone: an immunohistochemical study in man.

ARTESE, Luciano;PIATTELLI, Adriano;PERROTTI, Vittoria
2011-01-01

Abstract

Purpose: The aim of the present study was to perform a comparative histological and immunohistochemical evaluation of microvessel density, vascular endothelial growth factor, and nitric oxide synthase (NOS) expression in sinus augmentation using autologous bone alone or in combination with equine bone. Materials and Methods: Sixteen patients underwent sinus augmentation with autologous bone and a 50: 50 mixture of autologous and equine bone. Control cores were harvested from preexisting nonaugmented bone under the sinus floor. The specimens were processed for immunohistochemistry. Results: The greatest values of microvessel density were found in the sites grafted with autologous bone with significant differences between control versus autologous group (P < 0.01) and control versus autologous + equine group (P < 0.01). The higher and lower intensities of vascular endothelial growth factor and NOS3 expression were prevalent in the sites grafted with autologous bone with significant differences with the controls (P < 0.05). No significant differences (P > 0.05) were found in the NOS1 expression among the groups. Conclusion: The results obtained showed that the mixture of autologous and equine bone was biocompatible, and its use was associated with new blood vessels ingrowth during healing, which has been found to be extremely important for bone formation.
File in questo prodotto:
File Dimensione Formato  
2011-artese equino-Implant dent.pdf

Solo gestori archivio

Tipologia: Documento in Post-print
Dimensione 733.71 kB
Formato Adobe PDF
733.71 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/225815
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 29
social impact