Cytokines are immunomodulatory and infammatory compounds produced by many different cell types. The IL-1 family consists of at least eleven cytokines including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate infammation. IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells. IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE. Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and infammation. Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4. Here we review the interrelationship between PGD2, IL-1 family members and mast cells.
PGD2, IL1-FAMILY MEMBERS AND MAST CELLS
CASTELLANI, Maria Luisa;TRIPODI, Domenico;FELACO, PAOLO;TONIATO, ELENA;FULCHERI, Mario;TETE', Stefano;SALINI, VINCENZO;SABATINO, Giuseppe;
2010-01-01
Abstract
Cytokines are immunomodulatory and infammatory compounds produced by many different cell types. The IL-1 family consists of at least eleven cytokines including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate infammation. IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells. IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE. Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and infammation. Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4. Here we review the interrelationship between PGD2, IL-1 family members and mast cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
