Full-facial rejuvenation with autologous platelet-derived growth factors

The platelets used in oral, maxillofacial and plastic surgery are generally grouped as concentrated platelet rich plasma. The general principle of production consists of a centrifugation, making it possible to eliminate red blood cells, then acellular plasma, to preserve only the concentrated platelets. Aim to evaluate the efficacy of a three session of injections of autologous platelet-derived growth factors for full-face rejuvenation including the perioral and periorbital regions; 16 patients female between 27 and 60 years of age, were admitted to facial rejuvenation procedure. All these patients showed mainly class II rhytides. Six patients had rejuvenation of only the perioral region (five patients had class II rhytides and the other patient had class III rhytides). Another five patients had rejuvenation of only the periorbital region (two patients with class I rhytides, the other three had class II rhytides). Approximately 0,2 cc of autologous platelet-derived growth factors was produced per tube; this activated suspension was then injected intradermally or subdermally below the perioral and periorbital regions through 30 and 27 gauge needles, respectively, as needed to achieve the most optimal correction of the rhytides with mainly a linear threading technique. All patients demonstrated some improvement. 92.88% of participants were satisfied or very satisfied with their treatment result. The investigator evaluation rates of acceptable effect (score of 2 or 3) were 76.65%. The results lasted approximately 6 months with a gradual decline to baseline. Autologous platelet-derived growth factors in one treatment session for three months can achieve effective full-face skin rejuvenation, with effects on both the epidermis and dermis.