In the last years, the role of individual genetic background is considered critical in several aspects of medicine, such as susceptibility to diseases, disease progression, and responses to drug treatment [1]. Genomes from different individuals are 99.9 percent identical, with only 0.1 percent of the genome showing mutations [2]. Nevertheless, the constant improvement in genome analysis has contributed to produce a huge search for biologically active genomic polymorphisms, particularly single-nucleotide polymorphisms (SNPs), which consist of substitutions of one nucleotide for another in a DNA sequence [1]. The possibility that SNPs may contribute to identify genes responsible for common diseases as well as individuals at risk of disease had led to large studies focused on discovery and organization of SNPs into public databases.
Cox-2 polymorphisms and cardiovascular disease: elucidating the hidden side of the disease.
CIPOLLONE, Francesco
2009-01-01
Abstract
In the last years, the role of individual genetic background is considered critical in several aspects of medicine, such as susceptibility to diseases, disease progression, and responses to drug treatment [1]. Genomes from different individuals are 99.9 percent identical, with only 0.1 percent of the genome showing mutations [2]. Nevertheless, the constant improvement in genome analysis has contributed to produce a huge search for biologically active genomic polymorphisms, particularly single-nucleotide polymorphisms (SNPs), which consist of substitutions of one nucleotide for another in a DNA sequence [1]. The possibility that SNPs may contribute to identify genes responsible for common diseases as well as individuals at risk of disease had led to large studies focused on discovery and organization of SNPs into public databases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.