Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase‐dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice.

Role of Apoptosis in disease

FAVALORO, Bartolo;ALLOCATI, Nerino;DI ILIO, Carmine;DE LAURENZI, Vincenzo
2012-01-01

Abstract

Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase‐dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice.
File in questo prodotto:
File Dimensione Formato  
2012 Aging.pdf

accesso aperto

Tipologia: PDF editoriale
Dimensione 1.37 MB
Formato Adobe PDF
1.37 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/264239
Citazioni
  • ???jsp.display-item.citation.pmc??? 152
  • Scopus 434
  • ???jsp.display-item.citation.isi??? ND
social impact