Increase of swallows before the onset of phase III of migrating motor complex in normal human subjects

Abstract- The aim of our study was to analyze the relation between the deglutitive activity and fasting esophageal and gastric motility in normal subjects. Fifteen healthy subjects (9 males, 6 females) with a mean age of 42 years (range 19-65) were studied. A 24-hr pH-manometric recording was performed using a probe with four solid-state recording sites 10 cm apart, placed so as to record the motor activity of esophageal body, lower esophageal sphincter (LES) or distal part of the esophagus, and gastric antrum. An additional probe with one recording site was placed in the pharynx to evaluate swallowing. A pH electrode was also placed at 5 cm above the sphincter. Data were transferred to a personal computer and analyzed using specific software. Subjects received two meals during the recording session. MMCs were almost exclusively recorded during the nighttime. A mean of 2 +/- 0.94 (SD) MMC per subject was detected with a mean (+/- SD) interval, between each cycle, of 86.11 +/- 34.53 min. During the 30 min preceding gastric phase III, the number of swallows showed an increase that reached statistical significance 5 min before the onset of phase III. A similar pattern was observed for the area under the curve (AUC) of the esophagus and LES. In conclusion deglutition and esophageal motility vary with the MMC, suggesting that the deglutitive activity is part of the interdigestive motility pattern.