The "in vitro" immune effects of different Ti compounds on peripheral blood mononuclear cells (PBMC) were determined. The results show that Ti dioxide is not immunotoxic; Ti oxalate is strongly immunotoxic; titanocene inhibits cytokine release but not PBMC proliferation, while Ti ascorbate inhibits TNF-alpha release from PBMC but not that of IFN-gamma. The results show that Ti toxicity depends on speciation.
[Comparative in vitro study of various titanium compounds on the immune system].
DI GIAMPAOLO, LUCA;DI GIOACCHINO, Mario;BOSCOLO, Paolo
2003-01-01
Abstract
The "in vitro" immune effects of different Ti compounds on peripheral blood mononuclear cells (PBMC) were determined. The results show that Ti dioxide is not immunotoxic; Ti oxalate is strongly immunotoxic; titanocene inhibits cytokine release but not PBMC proliferation, while Ti ascorbate inhibits TNF-alpha release from PBMC but not that of IFN-gamma. The results show that Ti toxicity depends on speciation.File in questo prodotto:
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