Aliphatic and aromatic nitriles are converted to corresponding amides in a single step via hydrolysis with basic H(2)O(2) in aqueous solution of the surfactant Cetyltrimethylammonium methanesulfonate (CTAOMs). The method has several advantages: use and recycle of water as reaction medium, use of environmentally benign oxidant H(2)O(2), easy product isolation, short reaction time, high yields and selectivity, mild conditions.
Efficient Hydrolysis of Nitriles to Amides with Hydroperoxide Anion in Aqueous Surfactant Solutions as Reaction Medium
DI PROFIO, Pietro;
2009-01-01
Abstract
Aliphatic and aromatic nitriles are converted to corresponding amides in a single step via hydrolysis with basic H(2)O(2) in aqueous solution of the surfactant Cetyltrimethylammonium methanesulfonate (CTAOMs). The method has several advantages: use and recycle of water as reaction medium, use of environmentally benign oxidant H(2)O(2), easy product isolation, short reaction time, high yields and selectivity, mild conditions.File in questo prodotto:
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