Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNFα in their cytoplasmatic granules and release upon activation. TNF-alpha is a potent multifunctional cytokine involved in autoimmune diseases, cancer, allergy, and acute and chronic inflammation. In this study, we revisit the interrelationship between TNFα and mast cells.

Tumor necrosis factor-alpha and mast cells: Revisited study

TRIPODI, Domenico;CASTELLANI, Maria Luisa;TETE', Stefano;FELACO, PAOLO;DE LUTIIS, Maria Anna;FULCHERI, Mario;FELACO, Mario;CONTI, FIORELLA;NERI, Giampiero;PANDOLFI, Assunta;TONIATO, ELENA;
2011-01-01

Abstract

Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNFα in their cytoplasmatic granules and release upon activation. TNF-alpha is a potent multifunctional cytokine involved in autoimmune diseases, cancer, allergy, and acute and chronic inflammation. In this study, we revisit the interrelationship between TNFα and mast cells.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/350306
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