According to the most recent study of WHO, hypertension is estimated to cause over 7 million of deaths every year [1]. It is well known that hypertension represents a major risk factor for both coronary and cerebrovascular events, as it is a key factor for atherosclerosis development and progression. Indeed, its involvement has been proven since the first step of atherogenesis: the endothelial dysfunction. Despite it is only a monolayer tissue, endothelium is a complex and crucial homeostatic organ that plays a key regulatory role in vascular tone and structure. Endothelial cell stimulation induces the production and release of several vasoactive molecules, including nitric oxide, prostacyclin and others, which are able to reduce vascular smooth muscle cell (VSMC) tone, leukocyte adhesion and homing, and platelet adhesion [2].
Flow-mediated vasodilation: improving specificity for endothelial function evaluation
CIPOLLONE, Francesco;
2013-01-01
Abstract
According to the most recent study of WHO, hypertension is estimated to cause over 7 million of deaths every year [1]. It is well known that hypertension represents a major risk factor for both coronary and cerebrovascular events, as it is a key factor for atherosclerosis development and progression. Indeed, its involvement has been proven since the first step of atherogenesis: the endothelial dysfunction. Despite it is only a monolayer tissue, endothelium is a complex and crucial homeostatic organ that plays a key regulatory role in vascular tone and structure. Endothelial cell stimulation induces the production and release of several vasoactive molecules, including nitric oxide, prostacyclin and others, which are able to reduce vascular smooth muscle cell (VSMC) tone, leukocyte adhesion and homing, and platelet adhesion [2].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
