Ki-67 labeling index has been linked to patient outcome in breast cancer patients. However, very few published reports have examined Ki-67 labeling index in African breast cancer patients. Sixty-two Sudanese breast cancer patients with primary invasive tumors were immunostained for Ki-67, ER, PR, Her-2/neu, CK5/6, and CK17. Ki-67 labeling index ranged from 0% to 50%, with a median of 5%(interquartile range 0–10). Low Ki-67 labeling index (immunostaining < 10%) was detected in 43/62 (69.4%) with a median of 0 (interquartile range 0–5), whereas high Ki-67 labeling index (immunostaining ≥ 10%) was revealed in 19/62 (30.6%) with a median of 20 (interquartile range 12–26). Ki-67 labeling index was significantly associated with tumor grade (P = 0.022, Mann-Whitney U Test). There were no significant group differences between Ki-67 labeling index and ER (P = 0.43), PR (P = 0.7), Her-2/neu (P = 0.45), CK5/6 (P = 0.29), CK17 (P = 0.55), pathologic stage (P = 0.4), tumor histology (P = 0.99), breast cancer subtypes (P = 0.47), tumor size (P = 0.16), and age at diagnosis (P = 0.6). These results suggested that Ki-67 labeling index correlates with tumor differentiation and not with the tumor size or any other tested marker in Sudanese breast cancers. Thus, Ki-67 labeling index could be considered as a reliable measure of tumor proliferative fraction in Sudan.
Ki-67 Labeling Index in Primary Invasive Breast Cancer from Sudanese Patients: A Pilot Study.
MARIANI COSTANTINI, Renato;
2012-01-01
Abstract
Ki-67 labeling index has been linked to patient outcome in breast cancer patients. However, very few published reports have examined Ki-67 labeling index in African breast cancer patients. Sixty-two Sudanese breast cancer patients with primary invasive tumors were immunostained for Ki-67, ER, PR, Her-2/neu, CK5/6, and CK17. Ki-67 labeling index ranged from 0% to 50%, with a median of 5%(interquartile range 0–10). Low Ki-67 labeling index (immunostaining < 10%) was detected in 43/62 (69.4%) with a median of 0 (interquartile range 0–5), whereas high Ki-67 labeling index (immunostaining ≥ 10%) was revealed in 19/62 (30.6%) with a median of 20 (interquartile range 12–26). Ki-67 labeling index was significantly associated with tumor grade (P = 0.022, Mann-Whitney U Test). There were no significant group differences between Ki-67 labeling index and ER (P = 0.43), PR (P = 0.7), Her-2/neu (P = 0.45), CK5/6 (P = 0.29), CK17 (P = 0.55), pathologic stage (P = 0.4), tumor histology (P = 0.99), breast cancer subtypes (P = 0.47), tumor size (P = 0.16), and age at diagnosis (P = 0.6). These results suggested that Ki-67 labeling index correlates with tumor differentiation and not with the tumor size or any other tested marker in Sudanese breast cancers. Thus, Ki-67 labeling index could be considered as a reliable measure of tumor proliferative fraction in Sudan.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.