Few chemical compounds have demonstrated a controver- sial association with a specific disease such as arachidonic acid with atherothrombosis. Arachidonic acid metabolism is deeply linked to atherothrombosis because compounds gener- ated by this cascade, the eicosanoids, are key regulators of several pathophysiological processes critically involved in vessel homeostasis and blood clotting. After its release from membrane-bound phospholipids, arachidonic acid is metabo- lized by 4 main pathways: (1) prostaglandin (PG) endoperoxi- dase synthase, usually referred as cyclooxygenase (COX); (2) lipoxygenase; (3) P450 epoxygenase; and (4) nonenzymatic isoprostane biosynthesis...
EP Receptors and Coxibs: Seeing the Light at the End of the Tunnel
CIPOLLONE, Francesco;SANTOVITO, DONATO
2013-01-01
Abstract
Few chemical compounds have demonstrated a controver- sial association with a specific disease such as arachidonic acid with atherothrombosis. Arachidonic acid metabolism is deeply linked to atherothrombosis because compounds gener- ated by this cascade, the eicosanoids, are key regulators of several pathophysiological processes critically involved in vessel homeostasis and blood clotting. After its release from membrane-bound phospholipids, arachidonic acid is metabo- lized by 4 main pathways: (1) prostaglandin (PG) endoperoxi- dase synthase, usually referred as cyclooxygenase (COX); (2) lipoxygenase; (3) P450 epoxygenase; and (4) nonenzymatic isoprostane biosynthesis...I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
