Two simple and accurate methods for roxatidine assay in human serum and urine by derivative UV spectrophotometry are proposed. In serum the analyte is quantified after a solid-phase extraction procedure, whereas in urine it is determined after a selective extraction with 2-methylbutanol. In both methods the drug concentration is directly correlated with specific signals in the second and third derivative spectra of the sample extracts. Statistical analysis of the data from synthetic solutions confirms the good accuracy and precision of the methods.
Roxatidine estimation in human fluids by UV derivative spectrophotometry
CARLUCCI, Giuseppe;
1995-01-01
Abstract
Two simple and accurate methods for roxatidine assay in human serum and urine by derivative UV spectrophotometry are proposed. In serum the analyte is quantified after a solid-phase extraction procedure, whereas in urine it is determined after a selective extraction with 2-methylbutanol. In both methods the drug concentration is directly correlated with specific signals in the second and third derivative spectra of the sample extracts. Statistical analysis of the data from synthetic solutions confirms the good accuracy and precision of the methods.File in questo prodotto:
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