A method for the determination of famotidine in tablets and vials is described. The procedure is based on the use of the reversed-phase high-performance liquid chromatography, and of the second-derivative ultraviolet spectra, by utilizing the linear relationship between drug concentration and derivative peak amplitude. The minimum concentration detectable by derivative spectrophotometry was 0.5 μg/ml, and by HPLC 0.1 μg/ml. The relative standard deviations observed were approx. 1.5% for derivative spectrophotometry, and 1.2% for HPLC. The proposed methods, which give thoroughly comparable data, are simple and rapid, and allow one to obtain precise and accurate results.
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