A method for the determination of ofloxacin in pharmaceutical forms is described. The procedure is based on the use of the high-performance liquid chromatography, and of the second-derivative ultraviolet spectra, by utilizing the linear relationship between substance concentration and derivative peak amplitude. The minimum concentration detectable by derivative spectrophotometry was 20 ng/ml, and by HPLC 10 ng/ml. The proposed methods, which give thoroughly comparable data, are simple and rapid, and allow precise and accurate results.
Determination of Ofloxacin in Pharmaceutical Forms by High - Performance Liquid Chromatography and Derivative UV- spectrophotometry
CARLUCCI, Giuseppe;MAZZEO, PIETRO;
1993-01-01
Abstract
A method for the determination of ofloxacin in pharmaceutical forms is described. The procedure is based on the use of the high-performance liquid chromatography, and of the second-derivative ultraviolet spectra, by utilizing the linear relationship between substance concentration and derivative peak amplitude. The minimum concentration detectable by derivative spectrophotometry was 20 ng/ml, and by HPLC 10 ng/ml. The proposed methods, which give thoroughly comparable data, are simple and rapid, and allow precise and accurate results.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
