IRIS

Novel anti-inflammatory--pro-resolving mediators and their receptors.

RECCHIUTI, ANTONIO;
2011-01-01
2011
CURRENT TOPICS IN MEDICINAL CHEMISTRY
WOS:000288988600004
Inglese
ELETTRONICO
11
21261595
Resolution of inflammation, an actively coordinated program, is essential to maintain host health. It involves effective removal of inflammatory stimuli and the spatio-temporal control of leukocyte trafficking as well as chemical mediator generation. During the active resolution process, new classes of small, local acting endogenous autacoids, namely the lipoxins, D and E series resolvins, (neuro)protectins, and maresins have been identified. These specialized pro-resolving lipid mediators (SPM) prevent excessive inflammation and promote removal of microbes and apoptotic cells, thereby expediting resolution and return to tissue homeostasis. As part of their molecular mechanism, SPM exert their potent actions via activating specific pro-resolving G-protein coupled receptors. Together these SPM and their receptors provide new concepts and opportunities for therapeutics, namely promoting active resolution as opposed to the conventionally used enzyme inhibitors and receptor antagonists. This approach may offer new targets suitable for drug design for treating inflammation related diseases, for the new terrain of resolution pharmacology .
G-protein coupled receptor; inflammatory exudates; leukocytes; mediator lipidomics; omega-3 fatty acids; resolvins
2-s2.0-79952941296
sì
6
info:eu-repo/semantics/article
262
Serhan, C. N.; Krishnamoorthy, S.; Recchiuti, Antonio; Chiang, N. . Novel Anti Inflammatory Pro Resolving Mediators; Current Topics in Medicinal Chemi...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/524308
Citazioni
  • ???jsp.display-item.citation.pmc??? 146
  • Scopus 255
  • ???jsp.display-item.citation.isi??? 227
social impact