Thromboxane-Dependent Platelet Activation After Gastric Banding for Obesity.

Laparoscopic adjustable gastric banding (LAGB) is associated with persistent weight reduction but variable health outcomes.1 The molecular heterogeneity of obesity may lead to substantial variability among its specific subtypes.2 In severe obesity, bariatric surgery is the only treatment that results in considerable, persistent weight loss. Compared with usual care, bariatric surgery reduced cardiovascular events among obese adults.3 We demonstrated in vivo platelet activation in obese women free from other cardiovascular risk factors.4 Moreover, visceral obesity was characterized by systemic inflammation and enhanced lipid peroxidation. A substantial reduction of this mechanistic chain of events was achieved with a successful weight loss program.4 Our study investigated whether platelet activation and oxidative stress were persistently modulated by LAGB in nondiabetic, normotensive obese participants.