The present invention reports the synthesis and characterization of innovative PEGylated liposomes targeting therapeutic anti-apoptotic protein KillerTRAIL and the use of resulting therapeutic and targeted nanocarirers for anti-cancer and anti-inflammatory therapies. The synthesis of KillerTRAIL PEGylated liposomes were carried out by the conjugation of therapeutic proteins on the surface of nanocarriers and the anti-cancer activity in vitro was carried out in breast cancer cells which are us...
The present invention relates on an ex vivo method for the analysis, enumeration and/or classification and/or isolation of microvesicles present in whole biological fluid samples, in particular by flow cytometry
The present invention relates to a special type of non-internalizing binding moiety- drug-conjugates that specifically target LGALS3BP. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to LGALS3BP, said antibody being conjugated to cytotoxic drugs. The invention also comprises methods of the treatment of LGALS3BP-expressing cancer, including administering to a patient the disclosed drug conjugates and pharmaceutical preparations.
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