This review focuses on synthetic strategies developed to obtain serine-proline chimeras. The conformational properties of proline, combined with functional groups typical of aminoacid side chains, represent an interesting approach to stabilize peptide secondary structures such as β-turns. Different chemical pathways to synthesize 3-, 4-, and 5-hydroxyprolines, considered proline chimeras of aminoacid serine, will be presented and discussed. © 2016 Bentham Science Publishers.

Synthetic Strategies to Serine-Proline Chimeras: An Overview

AMMAZZALORSO, Alessandra;DE FILIPPIS, Barbara;MACCALLINI, Cristina;
2016

Abstract

This review focuses on synthetic strategies developed to obtain serine-proline chimeras. The conformational properties of proline, combined with functional groups typical of aminoacid side chains, represent an interesting approach to stabilize peptide secondary structures such as β-turns. Different chemical pathways to synthesize 3-, 4-, and 5-hydroxyprolines, considered proline chimeras of aminoacid serine, will be presented and discussed. © 2016 Bentham Science Publishers.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11564/650152
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