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EnglishNTRODUCTION: The delineation of Clinical Target Volume (CTV) is a critical step in radiotherapy. Several guidelines suggest different subvolumes and anatomical boundaries in rectal cancer (RC), potentially leading to a misunderstanding in the CTV definition. International consensus guidelines (CG) are needed to improve uniformity in RC CTV delineation. MATERIAL AND METHODS: The 7 radiation oncologist experts defined a roadmap to produce RC CG. Step 1: revision of the published guidelines. Step 2: selection of RC cases with different clinical stages. Step 3: delineation of cases using Falcon following previously published guidelines. Step 4: meeting in person to discuss the initial delineation outcome, followed by a CTV proposal based on revised and if needed, adapted anatomical boundaries. Step 5: peer review of the agreed consensus. Step 6: peer review meeting to validate the final outcome. Step 7: completion of RC delineation atlases. RESULTS: A new ontology of structure sets was defined and the related table of anatomical boundaries was generated. The major modifications were about the lateral lymph nodes and the ischio-rectal fossa delineation. Seven RC cases were made available online as consultation atlases. CONCLUSION: The definition of international CG for RC delineation endorsed by international experts might support a future homogeneous comparison between clinical trial outcomes.
International consensus guidelines on Clinical Target Volume delineation in rectal cancer. / Valentini, V; Gambacorta, Ma; Barbaro, B; Chiloiro, G; Coco, C; Das, P; Fanfani, Francesco; Joye, I; Kachnic, L; Maingon, P; Marijnen, C; Ngan, S; Haustermans, K.. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - STAMPA. - 120:2(2016), pp. 195-201.
| Titolo: | International consensus guidelines on Clinical Target Volume delineation in rectal cancer. |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Rivista: | |
| Citazione: | International consensus guidelines on Clinical Target Volume delineation in rectal cancer. / Valentini, V; Gambacorta, Ma; Barbaro, B; Chiloiro, G; Coco, C; Das, P; Fanfani, Francesco; Joye, I; Kachnic, L; Maingon, P; Marijnen, C; Ngan, S; Haustermans, K.. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - STAMPA. - 120:2(2016), pp. 195-201. |
| Abstract: | NTRODUCTION: The delineation of Clinical Target Volume (CTV) is a critical step in radiotherapy. Several guidelines suggest different subvolumes and anatomical boundaries in rectal cancer (RC), potentially leading to a misunderstanding in the CTV definition. International consensus guidelines (CG) are needed to improve uniformity in RC CTV delineation. MATERIAL AND METHODS: The 7 radiation oncologist experts defined a roadmap to produce RC CG. Step 1: revision of the published guidelines. Step 2: selection of RC cases with different clinical stages. Step 3: delineation of cases using Falcon following previously published guidelines. Step 4: meeting in person to discuss the initial delineation outcome, followed by a CTV proposal based on revised and if needed, adapted anatomical boundaries. Step 5: peer review of the agreed consensus. Step 6: peer review meeting to validate the final outcome. Step 7: completion of RC delineation atlases. RESULTS: A new ontology of structure sets was defined and the related table of anatomical boundaries was generated. The major modifications were about the lateral lymph nodes and the ischio-rectal fossa delineation. Seven RC cases were made available online as consultation atlases. CONCLUSION: The definition of international CG for RC delineation endorsed by international experts might support a future homogeneous comparison between clinical trial outcomes. |
| Handle: | http://hdl.handle.net/11564/657225 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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