Recent studies report an interesting role of Peroxisome Proliferator-Activated Receptors (PPAR) antagonists in different tumor models, being these compounds able to perturb metabolism and viability in cancer cells. In this work the identification of a novel PPAR antagonist, showing inhibitory activity on PPARa and a weaker antagonism on PPARg, is described. The activity of this compound and of a series of chemical analogues was investigated in selected tumor cell lines, expressing both PPARa and PPARg. Data obtained show a dose-dependent cytotoxic effect of the novel PPAR antagonist in colorectal and pancreatic cancer models.

Cytotoxic effect of a family of Peroxisome Proliferator-Activated Receptor antagonists in colorectal and pancreatic cancer cell lines

AMMAZZALORSO, Alessandra;DE LELLIS, LAURA;FLORIO, ROSALBA;BRUNO, ISABELLA;DE FILIPPIS, Barbara;FANTACUZZI, MARIALUIGIA;GIAMPIETRO, Letizia;MACCALLINI, Cristina;PERCONTI, SILVIA;VERGINELLI, Fabio;CAMA, Alessandro;AMOROSO, Rosa
2017-01-01

Abstract

Recent studies report an interesting role of Peroxisome Proliferator-Activated Receptors (PPAR) antagonists in different tumor models, being these compounds able to perturb metabolism and viability in cancer cells. In this work the identification of a novel PPAR antagonist, showing inhibitory activity on PPARa and a weaker antagonism on PPARg, is described. The activity of this compound and of a series of chemical analogues was investigated in selected tumor cell lines, expressing both PPARa and PPARg. Data obtained show a dose-dependent cytotoxic effect of the novel PPAR antagonist in colorectal and pancreatic cancer models.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/667549
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