Aims of the study: To evaluate physical growth of non-syndromic chidren affected by ARM and the impact on auxologic parameters of sex, type of defect and associated conditions. Methods: We retrieved retrospectively data on sex, level of defect (Krickenback's classification), associated malformations, weigth and heigth from birth to age 2 years, of non-syndromic ARM patients observed from 2001 to 2016. Complete data were available for 33 out of 80 cases (15m, 18 f). The z-scores for weigth and heigth were calculated for each patient, including z-score for heigth corrected for 63 genetic target. For parametric statistycal analysis, patients were grouped as isolated ARM (iARM, 13 pts) vs ARM with associated anomalies (aARM, 20 pts), ARM with colostomy (cARM, 9 pts) vs. ARM without colostomy (wcARM, 24 pts) female ARM (fARM) vs male ARM (mARM). Main results: In the overall group, weigth and heigth z-scores were negative along the entire study period but normalized around age 2. A significant difference among group for z-scores emerged among iMAR vs aMAR for weigth at 12 months (iMAR -0.2±1.2, aMAR -0.3±1.2; p=0.032) and for heigth at 1 (iMAR 1.1±0.5, aMAR 0.4±1.4; p=0.01) and 8 months (iMAR 0.3±1.3, aMAR 0.2±1.3; p=0.05) and among cARM vs wcARM for weigth at 3 (cARM -0.91±1.5, wcARM -1±1.5; p=0.04) and 12 months (cARM -0.32±1.2, wcARM -0.24±1.1; p=0.008) and for heigth at 3 (cARM -0.58±2, wcARM -0.55±1.9; p=0.002), 6 (cARM -0.72±1.4, wcARM -0.69±1.3; p=0.03) and 8 months (cARM -0.38±1.3, wcARM -0.22±1.3; p=0.02). Cconclusion: ARM patients are at risk of temporary growth delay during the first years of life, particularly those with complex conditions requiring frequent hospitalization or surgical procedures.
GROWTH TRENDS IN CHILDREN WITH ANO-RECTAL MALFORMATIONS (ARM) FROM BIRTH TO AGE 2 YEARS: THE ROLE OF COLOSTOMY AND ASSOCIATED ANOMALIES
LISI, GABRIELE;LELLI CHIESA, Pierluigi
2017-01-01
Abstract
Aims of the study: To evaluate physical growth of non-syndromic chidren affected by ARM and the impact on auxologic parameters of sex, type of defect and associated conditions. Methods: We retrieved retrospectively data on sex, level of defect (Krickenback's classification), associated malformations, weigth and heigth from birth to age 2 years, of non-syndromic ARM patients observed from 2001 to 2016. Complete data were available for 33 out of 80 cases (15m, 18 f). The z-scores for weigth and heigth were calculated for each patient, including z-score for heigth corrected for 63 genetic target. For parametric statistycal analysis, patients were grouped as isolated ARM (iARM, 13 pts) vs ARM with associated anomalies (aARM, 20 pts), ARM with colostomy (cARM, 9 pts) vs. ARM without colostomy (wcARM, 24 pts) female ARM (fARM) vs male ARM (mARM). Main results: In the overall group, weigth and heigth z-scores were negative along the entire study period but normalized around age 2. A significant difference among group for z-scores emerged among iMAR vs aMAR for weigth at 12 months (iMAR -0.2±1.2, aMAR -0.3±1.2; p=0.032) and for heigth at 1 (iMAR 1.1±0.5, aMAR 0.4±1.4; p=0.01) and 8 months (iMAR 0.3±1.3, aMAR 0.2±1.3; p=0.05) and among cARM vs wcARM for weigth at 3 (cARM -0.91±1.5, wcARM -1±1.5; p=0.04) and 12 months (cARM -0.32±1.2, wcARM -0.24±1.1; p=0.008) and for heigth at 3 (cARM -0.58±2, wcARM -0.55±1.9; p=0.002), 6 (cARM -0.72±1.4, wcARM -0.69±1.3; p=0.03) and 8 months (cARM -0.38±1.3, wcARM -0.22±1.3; p=0.02). Cconclusion: ARM patients are at risk of temporary growth delay during the first years of life, particularly those with complex conditions requiring frequent hospitalization or surgical procedures.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
