Fullerene C60 is a nanoparticle being actively investigated for possible applications in biology and medicine since, owing to its lipophilicity, it should be able to be incorporated in or to permeate across a cellular membrane. Once exposing cells to such nanoparticles, the problem becomes how to assess the actual presence of fullerene in cells. Here we used a home-made broadband near-field scanning microwave microscope, in both time and frequency domains, and a commercial scanning capacitance microscope to investigate the ability of fullerene to permeate MCF-7 breast cancer cells. We found that, while the electromagnetic properties of the cell membrane are changed by fullerene exposure, surface roughness is a more reliable indicator of fullerene exposure

Broadband near-field scanning microwave microscopy investigation of fullerene exposure of breast cancer cells

PIETRANGELO, Tiziana;
2016-01-01

Abstract

Fullerene C60 is a nanoparticle being actively investigated for possible applications in biology and medicine since, owing to its lipophilicity, it should be able to be incorporated in or to permeate across a cellular membrane. Once exposing cells to such nanoparticles, the problem becomes how to assess the actual presence of fullerene in cells. Here we used a home-made broadband near-field scanning microwave microscope, in both time and frequency domains, and a commercial scanning capacitance microscope to investigate the ability of fullerene to permeate MCF-7 breast cancer cells. We found that, while the electromagnetic properties of the cell membrane are changed by fullerene exposure, surface roughness is a more reliable indicator of fullerene exposure
978-150900698-4
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/670476
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