Peroxisome proliferator activated receptor α (PPARα) is ligand-activated transcriptional factor receptor belonging to nuclear receptors family. It plays a key role in lipid metabolism and glucose homeostasis and it is important in the prevention and treatment of metabolic diseases. PPARα has also a protective effects against brain cell death attributed to its anti-inflammatory and antioxidant properties. In the present work, we discuss the PPAR involvement in neurodegenerative pathologies and its potential as therapeutic target for these diseases.
PPARα as Potential Therapeutic Target for Neurodegenerative Diseases
Letizia Giampietro
;Rosa Amoroso
2017-01-01
Abstract
Peroxisome proliferator activated receptor α (PPARα) is ligand-activated transcriptional factor receptor belonging to nuclear receptors family. It plays a key role in lipid metabolism and glucose homeostasis and it is important in the prevention and treatment of metabolic diseases. PPARα has also a protective effects against brain cell death attributed to its anti-inflammatory and antioxidant properties. In the present work, we discuss the PPAR involvement in neurodegenerative pathologies and its potential as therapeutic target for these diseases.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
50254295232e72fdf884dbb13e42280cb375.pdf
Solo gestori archivio
Tipologia:
PDF editoriale
Dimensione
418.43 kB
Formato
Adobe PDF
|
418.43 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
