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EnglishTheplantsofEuphorbiagenushavebeenextensivelystudiedfortheirnutritiveandtherapeuticpurposes.Thepresentresearchistheforemostefforttoinvestigateandcomparethebiologicalactivitiesandchemicalcom-positionofdichloromethane(DCM)andmethanol(MeOH)solventextractsofEuphorbiamilliDesMoulaerialandroot parts. Antioxidant potential was determined using six different (FRAP, CUPRAC, Phosphomolybdenum,DPPH,ABTSandferrouschelation)methods.Theenzymeinhibitioneffectsofthetestedextractswereevaluatedagainst acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, α-amylase and tyrosinase.Similarly,theamountoftotalphenolicandflavonoidcontentswereassessedviaspectrophotometricmethodsandindividualsecondarymetaboliteswerealsodeterminedusingUHPLC-MSanalysis.MethanolicextractsfrombothaerialandrootpartscontainedthehighestcontentsforphenolicandflavonoidswhichtendstocorrelatewiththeirsignificantDPPH,ABTS(radicalscavenging),FRAP,CUPRAC(reducingpower)andα-glucosidaseinhibitionpotentials.While,boththeDCMextractscontainingthelowestbioactivecontentsweremostactiveinthephosphomolybdenumassay,cholinesterasesandtyrosinaseinhibition.Therootextractsprovedtobeabettersourceofbioactiveantioxidantmolecules.Additionally,UHPLC-MSprofilingofboththemethanolicextractsrevealedthepresenceoftotal16secondarymetabolitesbelongingtofivemajorgroups(phenolic,flavonoid,coumarin,glycosideandalkaloid).Toconclude,ourresultssuggestthatE.miliicanbeconsideredasapromisingleadoriginfornaturalbioactiveenzymeinhibitoryandantioxidantcompoundswhichcouldpavethewayforindustrialapplications
| Titolo: | In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive agents | |
| Autori: | ||
| Data di pubblicazione: | 2019 | |
| Rivista: | ||
| Abstract: | TheplantsofEuphorbiagenushavebeenextensivelystudiedfortheirnutritiveandtherapeuticpurposes.Thepresentresearchistheforemostefforttoinvestigateandcomparethebiologicalactivitiesandchemicalcom-positionofdichloromethane(DCM)andmethanol(MeOH)solventextractsofEuphorbiamilliDesMoulaerialandroot parts. Antioxidant potential was determined using six different (FRAP, CUPRAC, Phosphomolybdenum,DPPH,ABTSandferrouschelation)methods.Theenzymeinhibitioneffectsofthetestedextractswereevaluatedagainst acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, α-amylase and tyrosinase.Similarly,theamountoftotalphenolicandflavonoidcontentswereassessedviaspectrophotometricmethodsandindividualsecondarymetaboliteswerealsodeterminedusingUHPLC-MSanalysis.MethanolicextractsfrombothaerialandrootpartscontainedthehighestcontentsforphenolicandflavonoidswhichtendstocorrelatewiththeirsignificantDPPH,ABTS(radicalscavenging),FRAP,CUPRAC(reducingpower)andα-glucosidaseinhibitionpotentials.While,boththeDCMextractscontainingthelowestbioactivecontentsweremostactiveinthephosphomolybdenumassay,cholinesterasesandtyrosinaseinhibition.Therootextractsprovedtobeabettersourceofbioactiveantioxidantmolecules.Additionally,UHPLC-MSprofilingofboththemethanolicextractsrevealedthepresenceoftotal16secondarymetabolitesbelongingtofivemajorgroups(phenolic,flavonoid,coumarin,glycosideandalkaloid).Toconclude,ourresultssuggestthatE.miliicanbeconsideredasapromisingleadoriginfornaturalbioactiveenzymeinhibitoryandantioxidantcompoundswhichcouldpavethewayforindustrialapplications | |
| Handle: | http://hdl.handle.net/11564/698974 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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