CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishTheplantsofEuphorbiagenushavebeenextensivelystudiedfortheirnutritiveandtherapeuticpurposes.Thepresentresearchistheforemostefforttoinvestigateandcomparethebiologicalactivitiesandchemicalcom-positionofdichloromethane(DCM)andmethanol(MeOH)solventextractsofEuphorbiamilliDesMoulaerialandroot parts. Antioxidant potential was determined using six different (FRAP, CUPRAC, Phosphomolybdenum,DPPH,ABTSandferrouschelation)methods.Theenzymeinhibitioneffectsofthetestedextractswereevaluatedagainst acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, α-amylase and tyrosinase.Similarly,theamountoftotalphenolicandflavonoidcontentswereassessedviaspectrophotometricmethodsandindividualsecondarymetaboliteswerealsodeterminedusingUHPLC-MSanalysis.MethanolicextractsfrombothaerialandrootpartscontainedthehighestcontentsforphenolicandflavonoidswhichtendstocorrelatewiththeirsignificantDPPH,ABTS(radicalscavenging),FRAP,CUPRAC(reducingpower)andα-glucosidaseinhibitionpotentials.While,boththeDCMextractscontainingthelowestbioactivecontentsweremostactiveinthephosphomolybdenumassay,cholinesterasesandtyrosinaseinhibition.Therootextractsprovedtobeabettersourceofbioactiveantioxidantmolecules.Additionally,UHPLC-MSprofilingofboththemethanolicextractsrevealedthepresenceoftotal16secondarymetabolitesbelongingtofivemajorgroups(phenolic,flavonoid,coumarin,glycosideandalkaloid).Toconclude,ourresultssuggestthatE.miliicanbeconsideredasapromisingleadoriginfornaturalbioactiveenzymeinhibitoryandantioxidantcompoundswhichcouldpavethewayforindustrialapplications
| Titolo: | In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive agents |
| Autori: | |
| Data di pubblicazione: | 2019 |
| Rivista: | |
| Abstract: | TheplantsofEuphorbiagenushavebeenextensivelystudiedfortheirnutritiveandtherapeuticpurposes.Thepresentresearchistheforemostefforttoinvestigateandcomparethebiologicalactivitiesandchemicalcom-positionofdichloromethane(DCM)andmethanol(MeOH)solventextractsofEuphorbiamilliDesMoulaerialandroot parts. Antioxidant potential was determined using six different (FRAP, CUPRAC, Phosphomolybdenum,DPPH,ABTSandferrouschelation)methods.Theenzymeinhibitioneffectsofthetestedextractswereevaluatedagainst acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, α-amylase and tyrosinase.Similarly,theamountoftotalphenolicandflavonoidcontentswereassessedviaspectrophotometricmethodsandindividualsecondarymetaboliteswerealsodeterminedusingUHPLC-MSanalysis.MethanolicextractsfrombothaerialandrootpartscontainedthehighestcontentsforphenolicandflavonoidswhichtendstocorrelatewiththeirsignificantDPPH,ABTS(radicalscavenging),FRAP,CUPRAC(reducingpower)andα-glucosidaseinhibitionpotentials.While,boththeDCMextractscontainingthelowestbioactivecontentsweremostactiveinthephosphomolybdenumassay,cholinesterasesandtyrosinaseinhibition.Therootextractsprovedtobeabettersourceofbioactiveantioxidantmolecules.Additionally,UHPLC-MSprofilingofboththemethanolicextractsrevealedthepresenceoftotal16secondarymetabolitesbelongingtofivemajorgroups(phenolic,flavonoid,coumarin,glycosideandalkaloid).Toconclude,ourresultssuggestthatE.miliicanbeconsideredasapromisingleadoriginfornaturalbioactiveenzymeinhibitoryandantioxidantcompoundswhichcouldpavethewayforindustrialapplications |
| Handle: | http://hdl.handle.net/11564/698974 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11564/698974
Copyright © 2021