Diffusion-weighted MRI to assess response to chemoradiotherapy in rectal cancer: main interpretation pitfalls and their use for teaching

Lambregts, Doenja M. J.; van Heeswijk, Miriam M.; Delli Pizzi, Andrea; van Elderen, Saskia G. C.; Andrade, Luisa; Peters, Nicky H. G. M.; Kint, Peter A. M.; Osinga-de Jong, Margreet; Bipat, Shandra; Ooms, Rik; Lahaye, Max J.; Maas, Monique; Beets, Geerard L.; Bakers, Frans C. H.; Beets-Tan, Regina G. H.

doi:10.1007/s00330-017-4830-z

OBJECTIVES: To establish the most common image interpretation pitfalls for non-expert readers using diffusion-weighted imaging (DWI) to assess response to chemoradiotherapy in patients with rectal cancer and to explore the use of these pitfalls in an expert teaching setting. METHODS: Two independent non-expert readers (R1 and R2) scored the restaging DW MRI scans (b1,000 DWI, in conjunction with ADC maps and T2-W MRI scans for anatomical reference) in 100 patients for the likelihood of a complete response versus residual tumour using a five-point confidence score. The readers received expert feedback and the final response outcome for each case. The supervising expert documented any potential interpretation errors/pitfalls discussed for each case to identify the most common pitfalls. RESULTS: The most common pitfalls were the interpretation of low signal on the ADC map, small susceptibility artefacts, T2 shine-through effects, suboptimal sequence angulation and collapsed rectal wall. Diagnostic performance (area under the ROC curve) was 0.78 (R1) and 0.77 (R2) in the first 50 patients and 0.85 (R1) and 0.85 (R2) in the final 50 patients.

Titolo:	Diffusion-weighted MRI to assess response to chemoradiotherapy in rectal cancer: main interpretation pitfalls and their use for teaching
Autori:	Lambregts, Doenja M. J. van Heeswijk, Miriam M. DELLI PIZZI, ANDREA van Elderen, Saskia G. C. Andrade, Luisa Peters, Nicky H. G. M. Kint, Peter A. M. Osinga-de Jong, Margreet Bipat, Shandra Ooms, Rik Lahaye, Max J. Maas, Monique Beets, Geerard L. Bakers, Frans C. H. Beets-Tan, Regina G. H. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2017
Rivista:	EUROPEAN RADIOLOGY
Abstract:	OBJECTIVES: To establish the most common image interpretation pitfalls for non-expert readers using diffusion-weighted imaging (DWI) to assess response to chemoradiotherapy in patients with rectal cancer and to explore the use of these pitfalls in an expert teaching setting. METHODS: Two independent non-expert readers (R1 and R2) scored the restaging DW MRI scans (b1,000 DWI, in conjunction with ADC maps and T2-W MRI scans for anatomical reference) in 100 patients for the likelihood of a complete response versus residual tumour using a five-point confidence score. The readers received expert feedback and the final response outcome for each case. The supervising expert documented any potential interpretation errors/pitfalls discussed for each case to identify the most common pitfalls. RESULTS: The most common pitfalls were the interpretation of low signal on the ADC map, small susceptibility artefacts, T2 shine-through effects, suboptimal sequence angulation and collapsed rectal wall. Diagnostic performance (area under the ROC curve) was 0.78 (R1) and 0.77 (R2) in the first 50 patients and 0.85 (R1) and 0.85 (R2) in the final 50 patients.
Handle:	http://hdl.handle.net/11564/701919
Appare nelle tipologie:	1.1 Articolo in rivista

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