Molecular Evidences of Chlamydia trachomatis and Urogenital Mycoplasmas Infections from Birth Evolving into Multisite Infections

Several reports have documented the involvement of Chlamydia pneumoniae (Cp) and Mycoplasma pneumoniae (Mp) in neonates and children evolving later in asthma, chronic obstructive pulmonary disease (COPD) and chronic bronchitis (CB), depending on individual genetic susceptibility. In adult, either infection can cause, other more severe disease/syndrome on a time depending manner. Nowadays, these critical problems are well noted and the role of their human microbiome is emerging. However, an accurate scientific approach toward these individuals is not routinely carried out by analyzing patients from different department during the neonatal, early and late childhood, putting at risk the health of carriers, genetically susceptible of other latent pathologies. Even worse is the mental attitude of physician/specialist to approach routinely the clinical study of sexual atypical bacteria, such as Chlamydia trachomatis (Ct) and Urogenital Mycoplasmas [Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh)], at any time, leaving their veiled symptomatology still undervalued and consequently little investigated. An HLA-B27 positive 25 years old female, developed at birth, two days after premature delivery, a quite complex respiratory difficulty, occurring with coughing cough and upper respiratory symptoms (non-productive but persistent cough). Time course depending, the patient developed a chronic coughing cough (CCC), laryngopharyngeal reflux (LPR) and/or gastroesophageal reflux symptomatologies (GERD), showing a white line clinical sign and a multisite symptomatology leading to an evolutive inflammaging process, due to sexual atypical bacteria. Anamnesis, serological, hematological, immunological and microbiological analyses, based on cultural and molecular procedures, evidenced the presence of sexual atypical bacteria in all tissues investigated, clarifying the origin of initial oral contamination from atypical sexual Chlamydiaceae and Mycoplasmataceae, while their spreading into genetically susceptible target tissues was the reason of a precocious“inflammaging” process. The Hp-DNA negative results on oropharyngeal and periorbital sources excluded their involvement into a scenario of GERD and LPR reflux diseases. The Cp-DNA and Hp-DNA negative results on these tissues excluded their involvement in rosacea, remaining attributable only to Uu and Ct.