Binding between a component of the crude hot water extract obtained from Allium sativum crushed bulbs (ASw) and cholera toxin B pentamer (CTB) was detected by STD NMR experiments. Bioassay-oriented fractionation allowed the partial identification of a high molecular weight polysaccharide mainly composed of galactose as the bioactive complex against CTB. This work represents the first example of screening of a medicinal plant by NMR against a specific disease, and corroborates traditional medical uses of the species.

Screening of garlic water extract for binding activity with cholera toxin B pentamer by NMR spectroscopy - An old remedy giving a new surprise

Politi, Matteo
;
2006

Abstract

Binding between a component of the crude hot water extract obtained from Allium sativum crushed bulbs (ASw) and cholera toxin B pentamer (CTB) was detected by STD NMR experiments. Bioassay-oriented fractionation allowed the partial identification of a high molecular weight polysaccharide mainly composed of galactose as the bioactive complex against CTB. This work represents the first example of screening of a medicinal plant by NMR against a specific disease, and corroborates traditional medical uses of the species.
File in questo prodotto:
File Dimensione Formato  
EUr J Org Chem 2006 Politi.pdf

Solo gestori archivio

Tipologia: PDF editoriale
Dimensione 121.23 kB
Formato Adobe PDF
121.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11564/704105
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 18
social impact