BACKGROUND: Pain can be a frequent symptom during the natural history of a patient with pancreatic cancer. An increase in incidence with disease progression and the presence of unbearable pain may preclude a curative resection. MATERIALS AND METHODS: Even in those patients with resectable pancreatic cancer, the presence of pain has an impact on prognosis. To date, we do not really know why some patients develop pain. RESULTS: Perineural cancer cell invasion is one of the most intriguing characteristics of this neoplasia and may in some cases explain the pain sensation. In addition, so-called "neurogenic inflammation" might also play a role in pain generation in pancreatic cancer, just like in chronic pancreatitis. CONCLUSION: In conclusion, understanding the mechanisms of pain in pancreatic cancer could help patients because what counts is not only 5-year survival but also median survival with good quality of life

Pain and pain generation in pancreatic cancer

Di Mola F. F.;Di Sebastiano P.
2008

Abstract

BACKGROUND: Pain can be a frequent symptom during the natural history of a patient with pancreatic cancer. An increase in incidence with disease progression and the presence of unbearable pain may preclude a curative resection. MATERIALS AND METHODS: Even in those patients with resectable pancreatic cancer, the presence of pain has an impact on prognosis. To date, we do not really know why some patients develop pain. RESULTS: Perineural cancer cell invasion is one of the most intriguing characteristics of this neoplasia and may in some cases explain the pain sensation. In addition, so-called "neurogenic inflammation" might also play a role in pain generation in pancreatic cancer, just like in chronic pancreatitis. CONCLUSION: In conclusion, understanding the mechanisms of pain in pancreatic cancer could help patients because what counts is not only 5-year survival but also median survival with good quality of life
File in questo prodotto:
File Dimensione Formato  
Langenbecks Arch Surg 2008 Di Sebastiano.pdf

Solo gestori archivio

Tipologia: PDF editoriale
Dimensione 149.67 kB
Formato Adobe PDF
149.67 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/709789
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 28
social impact