Therapeutic strategies for organ-confined and non-organ-confined bladder cancer after radical cystectomy

Marchioni, M.; Nazzani, S.; Preisser, F.; Bandini, M.; Karakiewicz, P. I.

doi:10.1080/14737140.2018.1439744

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Introduction: In patients with muscle invasive or Bacillus Calmette-Guérin refractory urothelial carcinoma of the urinary bladder (UCUB) radical cystectomy represents the standard of care. However, a proportion of patients experience disease progression, local recurrence and/or metastatic disease. Areas covered: This review provides an overview of available therapeutic strategies after radical cystectomy and examines ongoing clinical trials including cytotoxic chemotherapy and immunotherapy. Expert commentary: Cytotoxic chemotherapy offers limited benefit in UCUB patients. However, the recent introduction of immunotherapy provides new hope for durable responses or possibly complete cures.

Titolo:	Therapeutic strategies for organ-confined and non-organ-confined bladder cancer after radical cystectomy
Autori:	MARCHIONI, MICHELE (Corresponding) Nazzani S. Preisser F. Bandini M. Karakiewicz P. I. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Rivista:	EXPERT REVIEW OF ANTICANCER THERAPY
Abstract:	Introduction: In patients with muscle invasive or Bacillus Calmette-Guérin refractory urothelial carcinoma of the urinary bladder (UCUB) radical cystectomy represents the standard of care. However, a proportion of patients experience disease progression, local recurrence and/or metastatic disease. Areas covered: This review provides an overview of available therapeutic strategies after radical cystectomy and examines ongoing clinical trials including cytotoxic chemotherapy and immunotherapy. Expert commentary: Cytotoxic chemotherapy offers limited benefit in UCUB patients. However, the recent introduction of immunotherapy provides new hope for durable responses or possibly complete cures.
Handle:	http://hdl.handle.net/11564/719518
Appare nelle tipologie:	1.1 Articolo in rivista

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