This 6-month prospective, single-arm observational study was designed to assess the effects of the KD on the nutritional status, resting energy expenditure (REE), and substrate oxidation in patients with drug-resistant epilepsy. Eighteen patients with medically refractory epilepsy underwent assessment of body composition, REE, and substrate oxidation rates before and after 6 months of KD. Compared with baseline, there were no statistically significant differences at 6 months in terms of height, weight, BMI z-scores, and REE. However, the respiratory quotient decreased significantly (from 0.800.06 to 0.720.05, p<0.001) whereas fat oxidationwas significantly increased (from50.925.2 mg/ min to 97.525.7 mg/min, p<0.001). Interestingly,we found that the increase in fat oxidationwas the main independent predictor of the reduction in seizure frequency (beta¼0.97, t¼6.3, p < 0.05). Administering a KD for 6 months in patients with medically refractory epilepsy increases fat oxidation and decreases the respiratory quotient, without appreciable changes in REE.

Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: A 6-month prospective observational study

BORRELLI, PAOLA;
2012

Abstract

This 6-month prospective, single-arm observational study was designed to assess the effects of the KD on the nutritional status, resting energy expenditure (REE), and substrate oxidation in patients with drug-resistant epilepsy. Eighteen patients with medically refractory epilepsy underwent assessment of body composition, REE, and substrate oxidation rates before and after 6 months of KD. Compared with baseline, there were no statistically significant differences at 6 months in terms of height, weight, BMI z-scores, and REE. However, the respiratory quotient decreased significantly (from 0.800.06 to 0.720.05, p<0.001) whereas fat oxidationwas significantly increased (from50.925.2 mg/ min to 97.525.7 mg/min, p<0.001). Interestingly,we found that the increase in fat oxidationwas the main independent predictor of the reduction in seizure frequency (beta¼0.97, t¼6.3, p < 0.05). Administering a KD for 6 months in patients with medically refractory epilepsy increases fat oxidation and decreases the respiratory quotient, without appreciable changes in REE.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11564/722447
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