COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.

Baricitinib restrains the immune dysregulation in severe COVID-19 patients

Iezzi, Manuela;
2020

Abstract

COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/741389
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