COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.
Baricitinib restrains the immune dysregulation in severe COVID-19 patients
Iezzi, Manuela;
2020-01-01
Abstract
COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.File in questo prodotto:
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2021 JCI Baricitinib.pdf
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